Pyramidal neuron

Active properties of neocortical pyramidal neuron dendrites.

Dendrites are the main recipients of synaptic inputs and are important sites that determine neurons' input-output functions. This review focuses on thin neocortical dendrites, which receive the vast majority of synaptic inputs in cortex but also have specialized electrogenic properties. We present a simplified working-model biophysical scheme of pyramidal neurons that attempts to capture the es...

Characterization of a Silicon Pyramidal Neuron

The Silicon Neuron is an analog VLSI circuit that has the functional characteristics of real neurons. The circuit emulates many of the ion conductances that generate action potentials and control the dynamics of their discharge. The ion conductances are modeled according to the Hodgkin-Huxley principles. The voltage dependence of the ion channels is achieved by a transconductance ampliier that ...

Pyramidal Neuron as Two-Layer Neural Network

The pyramidal neuron is the principal cell type in the mammalian forebrain, but its function remains poorly understood. Using a detailed compartmental model of a hippocampal CA1 pyramidal cell, we recorded responses to complex stimuli consisting of dozens of high-frequency activated synapses distributed throughout the apical dendrites. We found the cell's firing rate could be predicted by a sim...

Algorithmic description of pyramidal neuron populations from mouse neocortex

Pyramidal neuron conductance state gates spike-timing-dependent plasticity.

Neocortical neurons in vivo process each of their individual inputs in the context of ongoing synaptic background activity, produced by the thousands of presynaptic partners a typical neuron has. Previous work has shown that background activity affects multiple aspects of neuronal and network function. However, its effect on the induction of spike-timing dependent plasticity (STDP) is not clear...